Mon, Nov 07, 2022 page3

• PM2.5 can harm liver, kidneys: study

  CIRCULATORY SYSTEM: Researchers exposed laboratory mice to PM2.5 constituents, which caused inflammation in the liver and kidneys, and impaired kidney function

  • By Fang Chih-hsien and Liu Tzu-hsuan / Staff reporter, with staff writer
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  People should avoid vigorous outdoor exercise and use air purifiers indoors during peak PM2.5 pollution, as breathing polluted air could lead to liver and kidney injury in the long term, experts said, citing studies.

  Yuan Chung-shin (袁中新), a distinguished professor and director at National Sun Yat-sen University’s Institute of Environmental Engineering, and Cheng Fu-jen (鄭富仁), a doctor at Kaohsiung Chang Gung Memorial Hospital’s Department of Emergency Medicine, have published their findings in the journals Science of the Total Environment and Ecotoxicology and Environmental Safety.

  A research team led by Yuan and Cheng collected airborne particulate matter smaller than 2.5 micrometers (PM2.5) near Kaohsiung’s Linhai Industrial Park (臨海工業區) to study the effects of PM2.5 constituents on the livers and kidneys of laboratory mice.

  

  A map taken from the Environmental Protection Administration’s Web site shows the concentration of PM2.5 pollution across the nation as of 7pm yesterday.

  Photo: Screen grab from the Environmental Protection Administration Web site

  Studies have shown that PM2.5, which is listed by WHO as a Group 1 carcinogen, could harm the lungs and heart.

  The team separated PM2.5 into water extracts and insoluble particles, to which mice were exposed by intratracheal instillation.

  Exposure to water extracts and insoluble particles led to abnormal liver function and kidney injury, Cheng said.

  Insoluble particles caused inflammation in the liver, while water extracts induced cellular proliferation, which showed that different components of PM2.5 pose different health risks to the organ that removes toxins from the blood, he said.

  Water extracts and insoluble particles both caused inflammation and injury in the kidneys, he said, adding that PM2.5 might impair kidney function, which could lead to high blood pressure and constricted blood vessels.

  The mice were exposed to 40 micrograms of pollutants per week, similar to what they would have inhaled in Kaohsiung during winter, Yuan said.

  It was challenging to collect particulate matter, as the team had to take into consideration the wind direction and the matter’s concentration in the air, which is higher in spring and winter, but lower in summer and fall, he said.

  It took four sampling machines operating continuously for a month to collect 30,000 micrograms of PM2.5 for the experiment, he added.

  Water extracts of PM2.5 mainly include titanium, vanadium, nickel, lead, sulfate and nitrate, while insoluble particles mainly include organic carbons, elemental carbons, heavy metals and other chemicals, he said.

  “We might inhale some of the toxic elements while breathing,” he added.

  PM2.5 could cause acute asthma attacks and aggravate chronic obstructive pulmonary disease, he said, adding that long-term exposure could increase the risks of lung cancer, and kidney and liver injury through the circulatory system.
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