A UK clinical trial known as “Sentinel” is testing whether a small patch of skin from an organ donor can help detect lung transplant rejection at an earlier stage. The patch is grafted onto the patient’s forearm, making it possible to monitor visible changes such as rashes that may signal rejection before standard tests do. Scientists believe the skin may show signs of rejection earlier than other organs and is easier to observe directly.
In one case, a patient who received a lung transplant in 2024 noticed a purple rash on the patch, which led doctors to detect mild rejection early and begin steroid treatment promptly. The research team hopes the trial will improve understanding of transplantation and help patients live longer and healthier lives.
一項名為「Sentinel」的英國臨床試驗正在測試，來自器官捐贈者的一小片皮膚是否能幫助在較早階段偵測出肺臟移植排斥。這片皮膚會被移植到病患的前臂上，以監測像是皮疹等可能會比標準檢查更早顯示排斥反應的可見變化。科學家認為，皮膚可能會比其他器官更早出現排斥跡象，也更容易直接觀察。
Photo: Ivy English I 照片: 常春藤解析英語
在一個案例中，一名於 2024 年接受肺臟移植的病患注意到貼片上出現紫色皮疹，這讓醫師得以及早偵測到輕微排斥反應，並立即開始類固醇治療。研究團隊希望這項試驗能增進對移植的了解，並幫助病患活得更久、更健康。
What Did You Learn?
What is the purpose of using a skin patch in the Sentinel trial?
Photo: Ivy English I 照片: 常春藤解析英語
參考答案 :
1. To help detect lung transplant rejection at an earlier stage.
Words in Use
1. rejection n. 排斥
The patient was given medication to prevent rejection of the new organ.
那名病患被給予藥物以防止新器官產生排斥反應。
2. clinical a. 臨床的
Clinical data is needed before the drug can be approved.
該藥物獲得批准前需要臨床數據。
3. donor n. 捐贈者
Thanks to an organ donor, Michael was given a second chance at life.
多虧一位器官捐贈者，麥可獲得了重生的機會。
4. rash n. 皮疹，疹子
After using a new lotion, Emily developed a rash on her arm.
艾蜜莉使用新乳液後，手臂上長了皮疹。
5. mild a. 輕微的
The patient showed only mild symptoms after the procedure.
那名病患在手術後僅出現輕微症狀。
6. promptly adv. 迅速地，即刻地
The doctor began treatment promptly after the diagnosis.
醫生在診斷後立即開始治療。
Practical Phrases
1. graft A onto B 把 A 移植到 B 上
graft vt. 移植（皮膚、骨骼等）
Surgeons grafted healthy tissue onto Belle’s damaged skin.
外科醫生將健康組織移植到貝兒受損的皮膚上。
2. show signs of. . . 顯示……的跡象
During the long meeting, Ryan showed clear signs of fatigue and loss of focus.
在漫長的會議中，萊恩明顯出現疲憊與注意力喪失的跡象。
3. lead sb to V 使∕造成某人（做）……
The mistake led Jason to realize the importance of careful planning.
這個錯誤讓傑森體會到謹慎規畫的重要性。
聽文章朗讀及講解: https://ivy.pse.is/455bfu
本文出自常春藤解析英語雜誌: www.ivy.com.tw
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