Age may be a factor in battling the hepatitis B virus (HBV), researchers from National Taiwan University’s College of Medicine said yesterday.
Why a majority of adults infected with the virus are able to fight off the virus, while most infected newborns and toddlers end up developing a chronic hepatitis B infection has long baffled doctors and scientists.
Graduate Institute of Clinical Medicine associate professor Wang Hurng-yi (王弘毅), one of the authors of the research, said nearly 95 percent of adult-acquired hepatitis B infections lead to spontaneous clearance, while more than 90 percent of infected newborns and about 30 percent of infected children aged between one and five years old are unable to fight off the virus and subsequently develop a chronic infection.
“These statistics suggest that a person’s immune clearance of hepatitis B — which has affected nearly 2 billion people worldwide — is heavily age-related. However, as the reason for this remains unknown, our research team has made it its mission to find an answer,” Wang told a press conference in Taipei.
As a baby’s postnatal gut microbiota is not established until a toddler is two or three years old, the researchers presumed that gut commensals might be mainly responsible for preparing the liver’s immune system to fight the hepatitis B virus.
To prove this hypothesis, the researchers injected the virus into mice that ranged from from six-to-12 weeks old. They discovered that adult mice were able to clear the hepatitis B virus within six weeks after the injection, while their young remained hepatitis B virus-positive even after 26 weeks.
“We laced the drinking water of mice aged between five weeks and 12 weeks old with an antibiotic to have them gut-sterilized, resulting in a noticeable reduction in the level of gut bacteria DNA in stools,” Wang said.
Although the amount of stool bacteria in mice given antibiotics returned to normal shortly after antibiotic treatment ended, they were unable to clear the hepatitis B virus after they matured, Wang said.
The researchers also found that mice with the toll-like 4 receptor (TLR4) mutation were able to fight off the hepatitis B virus regardless of their age, offering a potential new treatment for neonates infected with hepatitis B at birth.
Chen Ding-shinn (陳定信), a hepatitis specialist and former head of the university’s College of Medicine, said more than half of the hepatitis B carriers in Taiwan caught the virus from their infected mothers during delivery.
“The link discovered between TLR4 deficiency in mice and the ability to clear HBV could be a giant step forward in finding ways to break the cycle of mother-to-newborn infection,” Chen said.
The research was published in the online version of the US journal Proceedings of the National Academy of Sciences on Monday.
EVA Air is prohibiting the use of portable chargers on board all flights starting from Saturday, while China Airlines is advising passengers not to use them, following the lead of South Korean airlines. Current regulations prohibit portable chargers and lithium batteries from check-in luggage and require them to be properly packed in carry-on baggage, EVA Air said. To improve onboard safety, portable chargers and spare lithium batteries would be prohibited from use on all fights starting on Saturday, it said. Passengers are advised to fully charge electronic devices before boarding and use the AC and USB charging outlets at their seat, it said. South
Hong Kong-based American singer-songwriter Khalil Fong (方大同) has passed away at the age of 41, Fong’s record label confirmed yesterday. “With unwavering optimism in the face of a relentless illness for five years, Khalil Fong gently and gracefully bid farewell to this world on the morning of February 21, 2025, stepping into the next realm of existence to carry forward his purpose and dreams,” Fu Music wrote on the company’s official Facebook page. “The music and graphic novels he gifted to the world remain an eternal testament to his luminous spirit, a timeless treasure for generations to come,” it said. Although Fong’s
WAR SIMULATION: The developers of the board game ‘2045’ consulted experts and analysts, and made maps based on real-life Chinese People’s Liberation Army exercises To stop invading Chinese forces seizing Taiwan, board gamer Ruth Zhong chooses the nuclear option: Dropping an atomic bomb on Taipei to secure the nation’s freedom and her victory. The Taiwanese board game 2045 is a zero-sum contest of military strategy and individual self-interest that puts players on the front lines of a simulated Chinese attack. Their battlefield game tactics would determine the theoretical future of Taiwan, which in the real world faces the constant threat of a Chinese invasion. “The most interesting part of this game is that you have to make continuous decisions based on the evolving situation,
China’s military buildup in the southern portion of the first island chain poses a serious threat to Taiwan’s liquefied natural gas (LNG) supply, a defense analyst warned. Writing in a bulletin on the National Defense and Security Research’s Web site on Thursday, Huang Tsung-ting (黃宗鼎) said that China might choke off Taiwan’s energy supply without it. Beginning last year, China entrenched its position in the southern region of the first island chain, often with Russia’s active support, he said. In May of the same year, a Chinese People’s Liberation Army Navy (PLAN) force consisting of a Type 054A destroyer, Type 055 destroyer,
RSS